ACLS · Algorithms · 2025 Guidelines
ACLS algorithms, explained the way the exam tests them
The core ACLS algorithms are six flowcharts: cardiac arrest, post-arrest care, bradycardia, tachycardia, ACS and stroke, all set by the 2025 AHA Guidelines for CPR and Emergency Cardiovascular Care (October 22, 2025). Run the 24 cards; each chart below explains a miss.
24 algorithm cards
Which statement about fluid resuscitation during cardiac arrest is correct?
Explanation
Keyed answerB. Fluid boluses should be administered when hypovolemia is suspected as a cause
Your pick
During cardiac arrest, routine fluid boluses are not recommended unless hypovolemia is suspected as a cause of the arrest. In cases where hypovolemia is a suspected cause, rapid infusion of isotonic crystalloid solution is appropriate to restore intravascular volume.
In ACLS protocols, why is it important to identify reversible causes of bradyarrhythmia such as hyperkalemia?
Explanation
Keyed answerB. It allows correction of the underlying condition without invasive procedures
Your pick
Identifying reversible causes allows clinicians to correct the underlying abnormality, potentially resolving the bradyarrhythmia without the need for invasive interventions like pacing.
Why is the administration of AV nodal blocking agents contraindicated in atrial fibrillation with rapid ventricular response in Wolff-Parkinson-White syndrome?
Explanation
Keyed answerA. They may promote conduction via the accessory pathway, increasing risk of ventricular fibrillation
Your pick
AV nodal blockers can preferentially block the conduction through the normal AV node, thereby promoting conduction through the accessory pathway, which may precipitate a dangerous ventricular arrhythmia.
In an elderly patient with bradycardia and a prolonged PR interval, what additional diagnostic modality can help uncover intermittent high-grade AV block?
Explanation
Keyed answerD. Holter monitoring
Your pick
Holter monitoring provides continuous ECG recording over an extended period, which can reveal intermittent episodes of high-grade AV block not seen on a single ECG.
Within the context of ACLS, when should antiarrhythmic agents like amiodarone be administered?
Explanation
Keyed answerD. After defibrillation and epinephrine in refractory shockable rhythms.
Your pick
They are indicated after defibrillation and epinephrine in refractory shockable rhythms, according to ACLS protocols.
Which of the following is the most appropriate pharmacological treatment for hemodynamically stable atrial fibrillation with rapid ventricular response in a patient with preserved ejection fraction?
Explanation
Keyed answerB. Metoprolol
Your pick
For stable atrial fibrillation with rapid ventricular response in patients with preserved ejection fraction, a beta-blocker like metoprolol is recommended to control the ventricular rate.
How does integrating pharmacologic strategies with timely defibrillation optimize outcomes in refractory ventricular arrhythmias?
Explanation
Keyed answerD. Timely medication administration combined with defibrillation helps terminate refractory arrhythmias.
Your pick
Sequential and coordinated interventions increase the likelihood of rhythm conversion by addressing both the electrical and biochemical aspects of arrest.
Which medication would be most appropriate for chemical cardioversion of new-onset atrial fibrillation in a patient with hypertrophic cardiomyopathy?
Explanation
Keyed answerB. Amiodarone
Your pick
Amiodarone is the preferred agent for chemical cardioversion in patients with hypertrophic cardiomyopathy as it has less negative inotropic effect compared to other antiarrhythmics. It also avoids the potential for increased outflow tract obstruction that can occur with some other agents.
Which of the following is a 'H' in the 'Hs and Ts' of potentially reversible causes of cardiac arrest?
Explanation
Keyed answerB. Hypovolemia
Your pick
Hypovolemia is one of the 'H's in the 'Hs and Ts' mnemonic for potentially reversible causes of cardiac arrest. The 'H's include Hypovolemia, Hypoxia, Hydrogen ion (acidosis), Hypo/Hyperkalemia, and Hypothermia.
What is the maximum total dose of atropine recommended for treating bradycardia in adults?
Explanation
Keyed answerC. 3 mg
Your pick
The maximum total dose of atropine for treating bradycardia in adults is 3 mg. Doses above this level are unlikely to produce additional beneficial chronotropic effects.
What is the recommended dose of calcium chloride for a patient with hyperkalemia-induced cardiac arrest?
Explanation
Keyed answerA. 10 mL of 10% solution (1 gram) IV/IO
Your pick
When calcium chloride is given for suspected hyperkalemia in cardiac arrest, the usual dose is 10 mL of a 10% solution (1 gram) IV/IO; calcium antagonizes the cardiac effects of a high potassium. Note that the 2025 AHA Guidelines describe the effectiveness of calcium in hyperkalemic cardiac arrest as not well established, and routine calcium in arrest is not recommended. High-quality CPR, defibrillation when indicated and treating the cause come first.
What is the appropriate initial management for a 68-year-old patient presenting with new onset atrial fibrillation with a ventricular rate of 160 bpm and normal blood pressure?
Explanation
Keyed answerC. Rate control with IV diltiazem or metoprolol
Your pick
For a hemodynamically stable patient with new-onset atrial fibrillation and rapid ventricular response, the initial approach is rate control with AV nodal blocking agents. IV diltiazem or beta-blockers like metoprolol are appropriate first-line medications to slow the ventricular rate.
Which antiarrhythmic medication is recommended for shock-refractory ventricular fibrillation or pulseless ventricular tachycardia after the third shock?
Explanation
Keyed answerD. Amiodarone 300 mg IV/IO
Your pick
Amiodarone is the recommended antiarrhythmic medication for shock-refractory ventricular fibrillation or pulseless ventricular tachycardia. The initial dose is 300 mg IV/IO bolus, with a second dose of 150 mg if needed.
Which finding on a 12-lead ECG best differentiates atrial flutter from other supraventricular tachycardias?
Explanation
Keyed answerC. Saw-tooth flutter waves in leads II, III, and aVF
Your pick
Atrial flutter typically presents with characteristic saw-tooth flutter waves (F waves) in the inferior leads (II, III, aVF), which represent rapid regular atrial activity at a rate of 250-350 bpm. This distinctive pattern helps differentiate atrial flutter from other supraventricular tachycardias.
What is a key consideration when interpreting end-tidal CO2 (ETCO2) values during cardiac arrest?
Explanation
Keyed answerC. Persistently low values often indicate poor cardiac output from inadequate CPR quality
Your pick
Persistently low ETCO2 during CPR usually means little blood is reaching the lungs, which most often points to poor compression quality. ETCO2 works as a real-time marker of CPR effectiveness: better compressions should raise it, and an abrupt, sustained rise can be a sign of return of spontaneous circulation (ROSC). The 2025 chart shows the trend without a number; the Guidelines text treats at least 10 mm Hg, ideally 20, as a sign the compressions are working.
What is the most appropriate initial management for a patient with a narrow-complex tachycardia at 170 bpm who is complaining of mild palpitations but has stable vital signs?
Explanation
Keyed answerD. Vagal maneuvers (e.g., Valsalva)
Your pick
For stable patients with narrow-complex tachycardia, vagal maneuvers are the recommended first step in management before proceeding to pharmacological interventions. These non-invasive techniques may terminate the arrhythmia by increasing parasympathetic tone.
Which of the following is the correct dose of sodium bicarbonate for a patient with prolonged cardiac arrest and suspected metabolic acidosis?
Explanation
Keyed answerC. 1 mEq/kg IV
Your pick
For patients with prolonged cardiac arrest and suspected metabolic acidosis, sodium bicarbonate can be considered at a dose of 1 mEq/kg IV. It is not routinely recommended in cardiac arrest but may be considered in specific situations like known preexisting hyperkalemia, tricyclic antidepressant overdose, or prolonged resuscitation with severe acidosis.
Which of the following medications can potentially exacerbate bradycardia and should be considered as a possible cause in patients presenting with symptomatic bradycardia?
Explanation
Keyed answerA. Beta-blockers (e.g., metoprolol)
Your pick
Beta-blockers like metoprolol can cause or exacerbate bradycardia by blocking beta-adrenergic receptors in the heart, reducing the influence of sympathetic stimulation on heart rate and conduction. Identifying and holding these medications is an important part of bradycardia management.
What is the maximum number of defibrillation attempts recommended before initiating CPR in witnessed VF cardiac arrest?
Explanation
Keyed answerB. One defibrillation attempt
Your pick
In witnessed VF cardiac arrest, one immediate defibrillation attempt is recommended before initiating CPR. After the initial shock, CPR should be performed for 2 minutes before reassessing the rhythm and potentially delivering additional shocks.
Which medication should be considered for rate control in atrial fibrillation for a patient with decompensated heart failure?
Explanation
Keyed answerD. Digoxin
Your pick
Digoxin is appropriate for rate control in atrial fibrillation in patients with decompensated heart failure as it doesn't have the negative inotropic effects that many other rate-controlling agents have, though its onset is slower than other options.
When should the first shock be delivered to a cardiac arrest victim found in a shockable rhythm?
Explanation
Keyed answerA. As soon as the AED/defibrillator is ready
Your pick
The first shock should be delivered as soon as the AED or defibrillator is ready. Early defibrillation for shockable rhythms is critical for survival, as the chances of successful defibrillation decrease with time.
Which of the following is a correct pairing of bradyarrhythmia and its appropriate pharmacological treatment?
Explanation
Keyed answerA. Symptomatic sinus bradycardia — Atropine
Your pick
Symptomatic sinus bradycardia is appropriately treated with atropine, which blocks parasympathetic (vagal) effects on the SA node, increasing the heart rate. Atropine is the first-line pharmacological treatment for symptomatic bradycardia according to ACLS guidelines.
According to ACLS guidelines, what is the recommended approach for a patient with refractory VF/pVT after standard treatment?
Explanation
Keyed answerC. Consider advanced interventions such as double sequential defibrillation, ECPR, or emergent PCI if available
Your pick
For VF/pVT that persists after standard treatment (defibrillation, CPR, epinephrine and an antiarrhythmic), the 2025 Guidelines say the usefulness of double sequential or vector-change defibrillation is not established, so it may be considered but is not routine; extracorporeal CPR (ECPR) where available and PCI for a suspected cardiac cause are the other options. Escalating epinephrine, stopping after three shocks and routine thoracotomy are not part of the algorithm.
A 45-year-old patient presents with sudden onset of regular narrow-complex tachycardia at 220 bpm. After two doses of adenosine failed to convert the rhythm, what is the most appropriate next step?
Explanation
Keyed answerA. Administer IV diltiazem
Your pick
After failed adenosine attempts for narrow-complex tachycardia, the next step is typically a longer-acting AV nodal blocking agent or an antiarrhythmic medication. IV diltiazem is appropriate for ongoing rate control in a hemodynamically stable patient with SVT that was refractory to adenosine.
0%
Answer a few cards and come back to this one.
- Cardiac arrestnot yet
- Brady & tachynot yet
The thin line on each bar marks 84%, the written-exam pass mark AHA Training Centers usually quote; your instructor confirms the exact rule.
Pick an answer and the card turns over to the explanation. Keys: A to D or 1 to 4, arrows to move, F to turn the card.
Map
The six ACLS algorithms and how the exam uses them
The ACLS Provider Course was updated to the 2025 Guidelines when they were released, and Training Centers had to teach from the new materials by March 1, 2026. So the charts the exam uses now are the 2025 set. They read as one system: every algorithm opens with a single question, and the answer sends you down one lane.
| Algorithm | Where it starts | The question that splits it | First moves |
|---|---|---|---|
| Cardiac arrest | No pulse, not breathing normally | Shockable rhythm or not? | CPR, then a shock or epinephrine |
| Post-cardiac arrest care | Return of spontaneous circulation (ROSC) | Following commands? | Airway, oxygen, blood pressure, 12-lead |
| Bradycardia | Pulse, rate typically under 50/min | Cardiopulmonary compromise? | Atropine, then pacing or an infusion |
| Tachycardia | Pulse, rate typically 150/min or more | Unstable? Then: wide QRS? | Synchronized cardioversion or drugs |
| Acute coronary syndromes | Chest pain or another ischemic picture | What does the 12-lead show? | Aspirin, 12-lead inside 10 minutes |
| Suspected stroke | Sudden neuro deficit | Bleed on the scan? | Last known normal, glucose, imaging |
The written exam drops you into the middle of a chart (third shock given, rhythm still VF: what now?) and asks for the next box. The Megacode asks for the same thing out loud, as orders to a team. Learn the splitting questions first; the boxes hang off them.
VF/pVT
Adult cardiac arrest algorithm: VF and pulseless VT
The ACLS cardiac arrest algorithm is one chart with two lanes. After CPR starts and the pads go on, the only question is whether the rhythm is shockable. VF and pulseless VT go to the shock lane; asystole and PEA go to the drug lane. Both lanes run in 2-minute cycles of CPR with a rhythm check at the end of each, and both carry epinephrine 1 mg every 3–5 minutes.
Cardiac arrest
- Start CPR. Bag-mask ventilation with oxygen, attach the monitor/defibrillator.
- Rhythm shockable?
Yes: VF or pVT
- Shock
- CPR 2 min · IV access (IO if IV fails)
- Shock if still VF/pVT
- CPR 2 min · epinephrine 1 mg every 3–5 min · consider advanced airway, capnography
- Shock if still VF/pVT
- CPR 2 min · amiodarone or lidocaine · treat reversible causes
- Rhythm check every 2 min. Still shockable: shock and keep cycling.
No: asystole or PEA
- Epinephrine 1 mg as soon as possible
- CPR 2 min · IV/IO access · epinephrine every 3–5 min · consider advanced airway
- Look for and treat the reversible causes
- Rhythm check every 2 min. Turned shockable: cross to the shock lane.
- Signs of ROSC: go to post-cardiac arrest care
ACLS shockable rhythms
Only two rhythms take a shock in arrest: ventricular fibrillation and pulseless ventricular tachycardia. Polymorphic VT without a pulse is treated as VF. Asystole and pulseless electrical activity (PEA) are never shocked, however chaotic the room feels.
The VF/pVT lane, shock by shock
01First shock
Shock as soon as the defibrillator is ready, then straight back on the chest for 2 minutes. No pulse check right after the shock.
02Second shock
Still VF or pVT at the rhythm check: shock, resume CPR, give the first epinephrine during that cycle. Access is IV first in 2025; intraosseous is the backup.
03Third shock
Still shockable: shock again, then amiodarone 300 mg (or lidocaine). The second amiodarone dose, 150 mg, comes on a later cycle if VF persists.
04Every cycle after
Shock, 2 minutes of CPR, epinephrine every 3–5 minutes, and a working list of reversible causes (the H’s and T’s).
| On the arrest chart | Dose | When |
|---|---|---|
| Epinephrine | 1 mg IV/IO | Every 3–5 min. Non-shockable: as soon as possible. Shockable: after the second shock |
| Amiodarone | 300 mg bolus, then 150 mg | Shock-refractory VF/pVT, around the third shock |
| Lidocaine (instead of amiodarone) | 1–1.5 mg/kg, then 0.5–0.75 mg/kg | Same slot as amiodarone |
| Biphasic shock | Manufacturer's dose (for example 120–200 J); unknown: maximum | Later shocks at least equivalent; higher may be considered |
| Monophasic shock | 360 J | Every shock |
The numbers behind high-quality CPR
CPR quality the chart assumes
- Rate
- 100–120 compressions/min
- Depth
- At least 2 inches (5 cm), full recoil
- No advanced airway
- 30:2
- Advanced airway
- 1 breath every 6 seconds (10/min), compressions continuous
- Breath size
- Visible chest rise: roughly a third to a half of an adult bag
- Compressor swap
- Every 2 min, sooner if tired
- Capnography
- ETCO₂ low or falling: fix CPR quality first
Most people revise the drug doses and skim these numbers, which is understandable and backwards: almost every arrest question assumes good compressions. If ETCO₂ is low or drifting down, the next step is better CPR, not another drug.
PEA
Asystole and PEA: the non-shockable lane
The ACLS algorithm for asystole and the ACLS algorithm for PEA are the same lane: CPR, epinephrine 1 mg as soon as possible, and a search for the reversible cause. Nothing in this lane is shocked, and there is no antiarrhythmic in it.
Asystole / PEA
- Pulseless, rhythm not shockable: asystole or an organized rhythm without a pulse (PEA)
- Epinephrine 1 mg IV/IO as soon as possible, then every 3–5 min
- CPR in 2-min cycles · consider advanced airway and waveform capnography
- Hunt the cause: hypovolemia, hypoxia, acidosis, potassium, hypothermia, tension pneumothorax, tamponade, toxins, pulmonary or coronary thrombosis
- Rhythm at the 2-min check?
Shockable
- Shock, then follow the VF/pVT lane
Not shockable
- Back to CPR and epinephrine; keep treating the cause
Organized rhythm
- Check a pulse. Pulse present: post-cardiac arrest care
PEA is the rhythm the exam uses to test causes. A monitor showing a tidy narrow-complex rhythm with no pulse means the electricity is fine and something mechanical or metabolic is not: empty tank, tension, tamponade, a clot, potassium. The stem usually hides the cause in one clue (a dialysis patient, a trauma, an opioid overdose), and the right answer treats it.
The ten causes, with the stem clue for each, are on the H’s and T’s page, which has its own 8-card deck.
ROSC
Post-cardiac arrest care algorithm
The post cardiac arrest algorithm starts the moment a pulse comes back and works top to bottom: airway, oxygen and ventilation, blood pressure, a 12-lead, then a single question about the brain. If the patient is not following commands, temperature control, EEG and delayed prognosis follow.
Post-arrest
- ROSC obtained
- Airway: place or exchange an advanced airway as needed; confirm with waveform capnography
- Oxygen and ventilation: 100% oxygen until SpO₂ reads reliably, then SpO₂ 90–98%; PaCO₂ 35–45 mm Hg
- Blood pressure: fluids and vasopressors to keep MAP ≥65 mm Hg
- Early tests: 12-lead ECG; consider CT and/or ultrasound to find the cause
- Following commands (off sedation)?
Yes
- Ongoing critical care; coronary angiography when appropriate
No or unsure
- Deliberate temperature control, 32–37.5 °C
- EEG for seizures · coronary angiography when appropriate
- Prognosis: multimodal, no earlier than 72 h
Post-ROSC targets, 2025
- SpO₂
- 90–98% (PaO₂ 60–105 mm Hg)
- PaCO₂
- 35–45 mm Hg, unless severe acidemia
- MAP
- At least 65 mm Hg
- Temperature
- One constant target, 32–37.5 °C, for at least 36 hours if not following commands
- Glucose
- Avoid under 70 mg/dL and over 180 mg/dL
- Prognosis
- Delayed: 72 hours or more after ROSC or normothermia
Three things moved in 2025, and old flashcards still carry the earlier versions. The oxygen saturation target now starts at 90%, not 92%. Temperature control is held for at least 36 hours, up from 24. And head-to-pelvis CT and point-of-care ultrasound after ROSC are now named as reasonable, to find the cause and any injury from the resuscitation.
ST elevation on the post-ROSC 12-lead, cardiogenic shock or recurrent VF/VT point to emergency coronary angiography. That cue appears in Megacode cases as often as on the written test.
Brady
ACLS bradycardia algorithm
The ACLS bradycardia algorithm turns on symptoms, not on the number. A heart rate typically under 50/min matters only when it causes cardiopulmonary compromise: hypotension, acutely altered mental status, signs of shock, ischemic chest discomfort or acute heart failure. Without those, you support, monitor and look for the cause.
Bradycardia
- Heart rate typically under 50/min and too slow for the clinical picture
- Support: airway, oxygen if needed, monitor, 12-lead, IV access; look for the cause
- Cardiopulmonary compromise? Hypotension, altered mental status, shock, ischemic chest discomfort, acute heart failure
No
- Monitor and observe; treat the cause
Yes
- Atropine 1 mg IV, repeat every 3–5 min, maximum 3 mg
- Atropine ineffective?
Yes
- Transcutaneous pacing and/or dopamine 5–20 mcg/kg/min or epinephrine 2–10 mcg/min
- Expert consultation; transvenous pacing
| Brady step | 2025 dose | Old number still in circulation |
|---|---|---|
| Atropine | 1 mg IV bolus, every 3–5 min, max 3 mg | 0.5 mg (pre-2020) |
| Dopamine infusion | 5–20 mcg/kg per minute, titrated; taper slowly | 2–20 mcg/kg per minute |
| Epinephrine infusion | 2–10 mcg per minute, titrated | unchanged |
| Transcutaneous pacing | If atropine is ineffective, alongside or instead of an infusion | unchanged |
Causes the chart lists: myocardial ischemia or infarction, drugs (calcium-channel blockers, beta-blockers, digoxin), hypoxia and electrolyte problems such as hyperkalemia. A stem that mentions a new beta-blocker is pointing at one of them.
Tachy
ACLS tachycardia algorithm: tachyarrhythmia with a pulse
The ACLS tachycardia algorithm, called the tachyarrhythmia with a pulse algorithm in the 2025 set, asks two questions in a fixed order. First: is this patient unstable because of the rate? If yes, synchronized cardioversion. If no: is the QRS wide (0.12 s or more) or narrow? That second answer picks the drugs.
Tachycardia
- Heart rate typically 150/min or more · airway, oxygen if hypoxemic, monitor, IV, 12-lead
- Unstable? Hypotension, altered mental status, shock, ischemic chest discomfort, acute heart failure
Yes: unstable
- Synchronized cardioversion, sedate whenever feasible
- Regular narrow complex: adenosine may be tried while you prepare
No: stable
- QRS 0.12 s or wider?
Wide
- Adenosine only if regular and monomorphic · procainamide or amiodarone infusion · expert consultation
Narrow
- Vagal maneuvers and adenosine (if regular) · beta-blocker or calcium-channel blocker
ACLS SVT: the narrow, regular rhythm
The 2025 chart says narrow-complex tachycardia where older ones said SVT; the treatment ladder is the same. Stable: vagal maneuvers, then adenosine 6 mg, then 12 mg, then a beta-blocker or a calcium-channel blocker. Unstable: synchronized cardioversion, with adenosine as an option only while the pads go on.
The ACLS afib algorithm runs through the same chart
There is no separate AF chart. Unstable atrial fibrillation gets synchronized cardioversion at 200 J or more; stable AF with a fast response gets rate control with a beta-blocker or a calcium-channel blocker. AF is irregular, so adenosine has no place in it. When the stem adds a pre-excitation history (Wolff-Parkinson-White), AV-nodal blockers become the wrong answer and expert help the right one.
| Rhythm | First synchronized shock | Note |
|---|---|---|
| Narrow-complex tachycardia | 100 J | Regular SVT that is unstable |
| Monomorphic VT with a pulse | 100 J | Regular, wide and monomorphic |
| Atrial fibrillation | At least 200 J | Raised for 2025; escalate if it fails |
| Atrial flutter | 200 J | Escalate if it fails |
| Polymorphic VT | Defibrillation dose, not synchronized | The monitor cannot sync to it |
Stable-tachycardia drugs, 2025 chart
- Adenosine
- 6 mg rapid IV push with a saline flush; 12 mg if needed
- Procainamide
- 20–50 mg/min until the rhythm breaks, hypotension, QRS widens over 50% or 17 mg/kg; avoid with long QT or heart failure
- Amiodarone
- 150 mg over 10 min, repeat if VT recurs; then 1 mg/min for the first 6 hours
Wide and polymorphic: the shock that must not be synchronized
Torsades and other polymorphic VT get the defibrillation dose, unsynchronized, the moment they cause instability. Sotalol is no longer on the 2025 chart; for stable monomorphic VT the infusions are procainamide or amiodarone.
ACS
Acute coronary syndromes algorithm
The ACLS acute coronary syndrome algorithm is a clock with an ECG in the middle. Aspirin and a 12-lead come first; the 12-lead sorts the patient into STEMI, high-risk NSTE-ACS or low-risk chest pain, and each lane has its own pace.
ACS
- Symptoms suggest ischemia or infarction
- Aspirin 162–325 mg · oxygen only if SpO₂ under 90% · nitroglycerin · morphine or fentanyl if pain persists
- 12-lead ECG acquired and read within 10 min of first medical contact
- What does the 12-lead show?
ST elevation
- STEMI: reperfusion if onset ≤12 h · PCI within 90 min of first contact, or fibrinolysis within 30 min of arrival
ST depression or dynamic T waves
- High-risk NSTE-ACS: risk score (TIMI or GRACE); early invasive strategy if troponin rises or risk is high
Normal or nondiagnostic
- Low or intermediate risk: monitor, serial ECGs and troponin
| ACS clock | Goal |
|---|---|
| 12-lead ECG | Within 10 minutes of first medical contact |
| Primary PCI (STEMI) | First medical contact to balloon 90 minutes or less |
| Fibrinolysis (STEMI, no timely PCI) | Door to needle 30 minutes |
| Portable chest X-ray | Within 30 minutes, never delaying the cath lab |
The 2025 chart dropped left bundle branch block as a definite STEMI equivalent, no longer names clopidogrel as the main antiplatelet, adds fentanyl beside morphine, and lists enoxaparin, fondaparinux and ACE inhibitors among the adjunctive drugs.
Stroke
ACLS algorithm for stroke
The ACLS algorithm for stroke is about time and one scan. Establish when the patient was last known normal, check glucose, get brain imaging fast, and let the scan decide: bleed or no bleed. No bleed opens the reperfusion lanes.
Stroke
- Stroke signs: activate the stroke protocol; note the time last known normal; check glucose
- Prehospital notification; on arrival straight to the brain imaging suite; NIH Stroke Scale
- Hemorrhage on CT or MRI?
Yes
- Intracranial hemorrhage protocol
No
- Thrombolytic candidate: alteplase or tenecteplase
- CTA (CT perfusion as indicated): large-vessel occlusion → endovascular therapy
- Stroke unit or neurological ICU
Stroke times the exam uses
- Brain imaging
- Within 20 minutes of arrival
- IV thrombolysis
- Standard window 4.5 hours from last known normal
- Endovascular therapy
- Selected patients up to 24 hours from last known normal
- Drugs
- Alteplase, or tenecteplase (added to the ACLS chart in 2025)
Doses
ACLS medication algorithm: every dose on one table
The ACLS medication algorithm is not a separate chart; it is the doses printed beside each flowchart. Here they are on one table, the way you would tab them in an open-resource exam.
| Drug or energy | 2025 dose | Where it belongs |
|---|---|---|
| Epinephrine (arrest) | 1 mg IV/IO every 3–5 min | Cardiac arrest, both lanes |
| Amiodarone (arrest) | 300 mg bolus, then 150 mg | Shock-refractory VF/pVT |
| Lidocaine (arrest) | 1–1.5 mg/kg, then 0.5–0.75 mg/kg | Alternative to amiodarone |
| Atropine | 1 mg every 3–5 min, max 3 mg | Symptomatic bradycardia |
| Dopamine infusion | 5–20 mcg/kg per minute | Bradycardia, atropine ineffective |
| Epinephrine infusion | 2–10 mcg per minute | Bradycardia, atropine ineffective |
| Adenosine | 6 mg rapid push, then 12 mg | Regular narrow (or regular monomorphic wide) tachycardia |
| Procainamide | 20–50 mg/min, max 17 mg/kg; then 1–4 mg/min | Stable wide-QRS tachycardia |
| Amiodarone (with a pulse) | 150 mg over 10 min; then 1 mg/min for 6 h | Stable wide-QRS tachycardia |
| Aspirin | 162–325 mg | Acute coronary syndromes |
| Defibrillation | Biphasic per manufacturer (e.g. 120–200 J); monophasic 360 J | VF, pVT, polymorphic VT |
| Synchronized cardioversion | 100 J narrow / monomorphic VT; 200 J flutter; ≥200 J AF | Unstable tachycardia with a pulse |
How often do you shock in ACLS? Once per 2-minute cycle, at the rhythm check, and only for VF or pulseless VT. For shock-refractory VF the 2025 Guidelines say the usefulness of vector-change and double sequential defibrillation is not established; neither is part of the standard algorithm the course tests.
2025
What changed in the 2025 ACLS algorithms
The 2025 AHA Guidelines for CPR and Emergency Cardiovascular Care were released on October 22, 2025. For the adult algorithms most of it is refinement: the arrest chart keeps its shape, and the epinephrine, amiodarone, lidocaine and atropine doses are the same as before. The changes below are the ones that turn a once-right answer into a wrong one.
| Topic | 2025 | Before |
|---|---|---|
| Vascular access in arrest | IV first; intraosseous if IV fails or is not feasible | IV first, as a weaker suggestion |
| Ventilation volume | Enough for visible chest rise, about a third to half of an adult bag | Visible chest rise, no bag-size cue |
| Post-ROSC oxygen | SpO₂ 90–98% | 92–98% |
| Post-ROSC blood pressure | MAP at least 65 mm Hg | SBP and MAP floors |
| Temperature control | One target, 32–37.5 °C, held at least 36 h if not following commands | At least 24 h (2020) |
| After ROSC imaging | Head-to-pelvis CT and point-of-care ultrasound may be reasonable | Not on the chart |
| AF cardioversion | At least 200 J; flutter 200 J | Device-specific, no number |
| Tachycardia chart | Sotalol removed; SVT renamed narrow-complex tachycardia | Sotalol listed |
| ACS chart | LBBB no longer a definite STEMI sign; fentanyl, enoxaparin, fondaparinux, ACE inhibitors added | LBBB counted; clopidogrel named; morphine only |
| Stroke chart | Tenecteplase added beside alteplase | Alteplase only |
| Chain of survival | One chain for adults and children, ending in recovery and survivorship | Separate in- and out-of-hospital chains |
The 2025 set also adds charts for cardiac arrest in pregnancy (delivery within 5 minutes of arrest as the goal) and for patients with a ventricular assist device. Neither is a core Megacode case, but both can appear as a written question.
Study
How to memorize the ACLS algorithms
01Learn the splitting questions
Shockable or not? Pulse or not? Unstable or not? Wide or narrow? Following commands or not? Five questions carry all six charts.
02Draw each chart from memory
Blank paper, one chart a day, then compare with the flowcharts above. The box you forget is the one to tab in the manual.
03Say it as orders
The Megacode wants the chart spoken to a team: “Charging to 200, everyone clear, shock.” Run one case aloud every evening.
04Drill the deck above by chip
Two chips, arrest and brady/tachy, 12 cards each. Redo the chip you scored lower on the next day.
05Test the whole spread
Then take the 60-card practice test or the practice questions by topic; the Study guide sets the order for the rest of the course.
The six charts in five lines
- Arrest: one shock, 2 minutes of CPR, rhythm check; epinephrine early in asystole/PEA, after the second shock in VF/pVT.
- After ROSC: SpO₂ 90–98%, PaCO₂ 35–45, MAP ≥65, temperature control for 36 hours if not following commands.
- Brady: symptoms decide; atropine 1 mg, then pacing or an infusion.
- Tachy: unstable means synchronized cardioversion; stable means wide-or-narrow, then drugs.
- ACS and stroke: a 12-lead in 10 minutes; a scan before any clot-busting decision.
FAQ
Questions people ask
What are the algorithms for ACLS?
Six core charts: adult cardiac arrest (VF/pVT and asystole/PEA), post-cardiac arrest care, bradycardia with a pulse, tachycardia with a pulse, acute coronary syndromes and suspected stroke. The 2025 set adds cardiac arrest in pregnancy and a ventricular assist device chart.
What are the most current ACLS algorithms?
The ones built on the 2025 AHA Guidelines for CPR and Emergency Cardiovascular Care, released on October 22, 2025. The ACLS Provider Course was updated to the 2025 Guidelines when they were released, and courses moved to the new materials by March 1, 2026.
Are there new ACLS guidelines for 2026?
No new set. The 2025 Guidelines are current through 2026; what changed in 2026 is that classes switched to the 2025 course materials by March 1, 2026. The list of 2025 changes shows what is new.
How often do you shock in ACLS?
Once per 2-minute CPR cycle, at the rhythm check, and only for VF or pulseless VT. No stacked shocks, and compressions restart straight after each one.
What are the shockable rhythms in ACLS?
Ventricular fibrillation and pulseless ventricular tachycardia (polymorphic VT without a pulse is treated as VF). Asystole and PEA are not shockable.
How do you memorize the ACLS algorithms?
Learn the five splitting questions (shockable, pulse, stable, wide, following commands), draw one chart a day from memory, and say it as team-leader orders. Then drill the deck on this page by chip.
What is the difference between ACLS and BLS?
BLS is compressions, breaths and the AED. ACLS builds on it with rhythm reading, drugs, manual defibrillation, airways and team leading; BLS provider skills are expected before you start.
What is the most current ACLS manual?
The ACLS Provider Manual written to the 2025 Guidelines. Older 2020 manuals still circulate; your Training Center tells you which edition your class uses.
One more cycle, then rest
The exam asks for the next right step, one at a time. Practice exactly that: one card, one decision.